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KMID : 0359720230410020145
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Journal of the Korean Neurological Association
2023 Volume.41 No. 2 p.145 ~ p.148
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A Case of de novo MPO-associated Central Nervous System Vasculitis Following Heterogeneous mRNA1273 COVID-19 Booster Vaccination
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Jeong Young-Seok
Bang Sung-Jo
Kim Geun-Yeong
Jeon Jae-Ho
Oh Gi-Ryeong
Chung Chong-Hyuk
Park Hyung-Jong
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Abstract
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The coronavirus disease-19 (COVID-19) pandemic leaded to inevitable expeditious vaccine rollout without sufficient safety profile. Especially, severe acute respiratory syndrome coronavirus 2 infection has known to induce overreacted immune responses such as releasing of proteinase-3 and myeloperoxidase (MPO) by neutrophil. This overreacted immune response leads to the concern of the development of autoimmune diseases after COVID-19 vaccination. We report the case of de novo MPO-associated systemic vasculitis involving central nervous system following heterogeneous mRNA1273 COVID-19 booster vaccination.
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KEYWORD
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Coronavirus, Antibodies, antineutrophil cytoplasmic, Vasculitis
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